Usizo lwezifo ze-neurological
I-Creatine ingenye yezithako ezicwaningwa kakhulu futhi ezisetshenziselwa kabanzi ukuthuthukisa ukukhula kwamasipha namandla. Kuyinto ethandwa phakathi kwezemidlalo, izakhi zomzimba kanye nalabo abafuna ukuthuthukisa ukusebenza kwezemidlalo. I-Creatine iboniswe ukuthi ingenye yezinto ezingcono eziqinisekisiwe ezisekelwe ebufakazini ezemidlalo . Nakuba kuboniswe ukuthuthukisa ukuthuthukiswa kwemisipha, i-creatine iphinde iphakanyiswe ukuthi ibasize kulabo ababhekene nezifo ze-neurological.
Ucwaningo oluqhubekayo luqhubeka nokusekela i-creatine edlala indima ezuzisayo ohlelweni lwezinzwa zomphakathi (CNS). Kubonakala ukwengezwa kwe-creatine kunganciphisa izimpawu zezifo ezingenayo i-neurodegenerative njenge-Alzheimer's, i-Parkinson, i-ALS, ne-Huntington.
Yini i-Creatine?
I-Creatine yinto eyenzeka ngokwemvelo eyenziwe ngamamino acids glycine, arginine, ne-methionine. Ama-amino acids yizakhi zokwakha amaprotheni. I-Creatine ikhiqizwa esibindi, izinso, nama-pancreas futhi igxile ikakhulukazi emathisini emisipha. Amanani amancane asakazwa ngegazi lethu ebuchosheni nakwezinye izicubu.
I-Creatine itholakala emithonjeni yamaprotheni ezinyamazane njenge inyama nenhlanzi ngaphezu kokukhiqizwa emzimbeni.
Isebenza kanjani Emzimbeni Wethu
I-Creatine inesibopho sokunikezela amandla kumaseli ngaphakathi komzimba nokugcina imisebenzi yethu yeselula ibhalansi. Kwenzeka ngokwemvelo futhi kuhlinzekwa ngokusebenzisa ukudla nokudla okunye.
Uma i-creatine ingena noma ikhiqizwa ngumzimba, ihamba ngezinqubo zamakhemikhali namafomu okudala i-phosphate . Le molecule egcinwe inikeza amandla okusheshayo kwamaseli aphelile ngesikhathi somzamo omkhulu womzimba noma we-neuronal.
I-creatine phosphate ibizwa nangokuthi i-phosphocreatine (PCr). I-Creatine ithuthukisa ukuzivocavoca ukusebenza ngokukhuphula i-PCr noma i-ATP (i-adenosine tri-phosphate). I-ATP ingenye imithombo yamandla esetshenziswa ngesikhathi sokushisa okusheshayo kwamandla njenge-sprinting noma ukuphakamisa isisindo.
Ifomu yokugcina i-creatine (i-phosphocreatine) iyona mthombo oyinhloko wamandla okudingeka usebenzise ukuqhuma okusheshayo kokuzivocavoca okukhulu. Abadlali bezezela nge-creatine ngenxa yokukwazi ukunikeza amandla nokwandisa usayizi we-muscle.
I-Creatine iye yaba ngaphezu kokuthuthukiswa komdlali . Ucwaningo luye lwabonisa ukuthi i-creatine inenani elibalulekile ekwelapheni isifo se-neurodegenerative. Ikhono lokwelapha ukukhomba ukukhubazeka kwamandla eselula kunganciphisa izimpawu zezifo zezinzwa ezigulini.
I-Creatine ne-Neurological Research
Ngokusho kocwaningo olwanyatheliswa kuyi- Journal of Nelomolecular Medicine, i- creatine iboniswe ukuthi iyindlela yokwelapha ephumelelayo yesifo sikaHuntington sikaParkinson. Kubonakala i-creatine ithuthukisa ukulahlekelwa kwamandla eselula kumathishu ebuchopho ekunciphiseni izimpawu zalezi zinkinga ze-neurodegenerative.
Ucwaningo olwenziwe nge-long-term creatine supplementation lokuhlola imiphumela emibi nalo lwaluqhutshwa. Iziguli ezineminyaka engamashumi ayisithupha ubudala zihlolwe iminyaka engu-2 futhi zithole ama-4g / d we-creatine noma i-placebo. Ukugxila kwakuyinhloko ukuqinisekisa ukuthi umsebenzi wokuqeda amandla kufanele usebenze ngenkathi uhlanganisa ne-creatine yezifo zezinzwa. I-Creatine yaboniswa ukuba ibekezeleleke kahle iziguli ezindala ezivela esibhedlela sikaParkinson. Isolo noma umsebenzi wezinyosi uhlale ngaphansi kwemingcele evamile futhi kuphela umphumela obi wecala kubonakala sengathi uphazamisekile ngesisu ngesinye isikhathi.
Ezinye izifundo zibonisa ukwesekwa kwe-creatine ukuze kuthuthukiswe ukuhlushwa kwengqondo nokukhumbula abantu abanempilo kanye neziguli zesifo se-Alzheimer's early stage.
Ukwenziwa kocwaningo kwenzelwa iziguli eziphethwe yiLou Gehring Disease. Lesi sifo sezinzwa siphumelela ama-neurons wesistimu ye-central central. I-Creatine iboniswe ukunikeza umphumela we-neuroprotective.
Ngokuvamile, ukwengezwa kwe-creatine kuboniswa ukuhlinzeka ngokuvikelwa kwezinzwa kwamaseli. Ucwaningo oluqhubekayo lubonisa i-creatine ukuba i-agent esebenzayo ye-neuroprotective. Iziguli ezithatha i-creatine ziye zathola ukuthuthukiswa komsebenzi kanye nekhwalithi engcono yokuphila.
Ithemba Ngezifo Zezinzwa
Kungase kube nethemba kulabo ababhekene nezifo zezinzwa njenge-Parkinson's, Alzheimer's, Amyotrophic Lateral Sclerosis (ALS), kanye noHuntington.
I-Creatine ibonakala idlala indima ebalulekile ekugcineni ibhalansi yamandla eselula. Ucwaningo lubonise imiphumela ethembisayo ekunciphiseni ukuqhubeka kwezifo ezithile zezinzwa.
Kubonakala sengathi kunesibonakaliso esinamandla sokwesekwa kwe-creatine njengendlela yokwelashwa yokwelapha isifo sezinzwa. Imiphumela etholakalayo isekela ucwaningo oluqhubekayo.
Isifo ngasinye sesifo sezinzwa sinezinkinga ezihlukene zamandla ezingase zingenakuzuzwa ekufakeni ukwesekwa kwe-creatine. Isifo se-Alzheimer (AD) sibonelo sitholakale ukukhombisa ukuthuthukiswa nge-supplementation ye-creatine kuphela ezinkathini zokuqala. Ngokuhamba kwesikhathi ukwelashwa kwe-AD akuzange kuphumelele ngenxa yokudala ama-deposit atholakele ebuchosheni.
Isifo se-Parkinson (PD) sokuhlolwa kwemitholampilo sibonakalise amandla okuba ne-creatine supplementation ukuze kunciphise ukuqhubekela phambili kwe-PD. I-Creatine ibonakala inenzuzo yesikhathi eside kubantu abakhuluma nge-PD njengamanje.
I-Amyotrophic Lateral Sclerosis (ALS) ngeshwa futhi ngokufanayo nesifo se-Alzheimer (AD) asizange siphendule ngempumelelo ekudaleni ukwengezwa.
I-supplementation ye-Creatine yabonisa amandla amakhulu ekwelapheni kwesifo sikaHuntington (HD). Ukucwaninga kubonisa ubufakazi obunamandla ekusebenzeni njenge-agent esebenzayo ye-neuroprotective yalesi sifo. I-Creatine ingathuthukisa futhi / noma ikhulise ikhwalithi yokuphila kubantu abanesifo se-HD.
> Imithombo:
> Andreas Bender et al., Ukwesekwa okudala kwe-creatine kuphephile kwiziguli ezindala ezinezifo ze-Parkinson, Research Nutrition , 2008
> I-Journal of Biomedicine ne-Biotechnology, i-US National Library of Medicine, i-National Institutes of Health, i-Creatine Kinase / Creatine Connection kwi-Alzheimer's's Disorders: i-CK Inactivation, i-APP-CK Complexes, ne-Focal Creatine Deposits, u-Tanja S. Bürklen et al., 2006.
> I-Journal Official ye-American Academy of Neurology, neurology.org, PRECREST: Isivivinyo sesigaba sesibili sokuvimbela kanye nesimanga se-creatine esengozini yokuHuntington, uHerminia D. Rosas, MD et al., 3/11/14
> I-Journal Official ye-American Academy of Neurology, i-neurology.org, Isivivinyo somtholampilo esingahleliwe, esingenasiphuphuphukuphuluki, esingenasisekelo sokudala kanye ne-minocycline ekuqaleni kwesifo se-Parkinson, uDkt. Bernard Ravina, 3/14/06
> I-Library Kazwelonke Yezokwelapha yase-US, Izikhungo Zikazwelonke Zempilo, i-Subcellular Biochemistry, Indima ye-neuroprotective ye-creatine, uKlein AM, Ferrante RJ, 2007