Izindleko ze-CONTRAVE, Imiphumela Eceleni kanye Nemiphumela Yomculo
Uma udinga ukulahlekelwa isisindo futhi ufuna imithi yokulahlekelwa kwesisindo somzimba , unezinketho eziningana. Udokotela wakho angakhuluma nawe ngeBelviq , Qsymia , Saxena noma enye imithi ebizwa ngokuthi i-CONTRAVE (bupropion ne-naltrexone). Nakhu okudingeka ukwazi mayelana ne-CONTRAVE, kufaka phakathi izindleko, imiphumela yokulahlekelwa isisindo, nemiphumela emibi.
Kuyini i-CONTRAVE?
I-CONTRAVE iyinhlanganisela yemithi emibili ehlukene: naltrexone hydrochloride ne-bupropion hydrochloride.
Ithebulethi ngayinye yokukhululwa iqukethe:
- ama-milligram ayisishiyagalolunye okuthiwa i-naltrexone, i-opioid agonist ejwayele ukuchazwa ngokuxhomeka kotshwala, ukuxhomeka kwe-opioid, noma ukubhema ukuyeka ukuphathwa
- 90 milligrams of bupropion, i-anti-depressant i-aminoketone esetshenziselwa ukuphatha ukucindezeleka kanye nenkinga yokucindezeleka yonyaka
Ukuhlanganiswa kwemithi emibili kunqunyelwe ukuthuthukisa ukulahlekelwa kwesisindo. Isidakamizwa sithinta isimiso sakho sezinzwa zomphakathi ukwandisa inani lamakholori oshisa futhi unciphise ukudla kwakho. Amaphilisi anqunywe kanye nokudla okunciphise-khalori nokuzivocavoca ukusiza abantu abathile ukuba balahlekelwe isisindo.
I-CONTRAVE ikhiqizwa ngu-Orexigen futhi isakazwa ngu-Takeda.
Ngubani ongathatha i-CONTRAVE?
I-CONTRAVE ivunyelwe ukusiza abantu abadala abadala abane- index mass (BMI) yabantu abayi-30 noma ngaphezulu noma abakhuluphele kakhulu abane-BMI abangama-27 noma ngaphezulu abanesimo esisodwa esisithinta isisindo esinjenge-cholesterol ephakeme, uhlobo lwesifo sikashukela se-2 noma i-high blood ukucindezela.
Abantu abathile akufanele bathathe i-CONTRAVE. Gwema imithi uma:
- ube nomthamo wegazi ophezulu ongalawuleki
- une-disorder disorder, anorexia nervosa, noma i-bulimia
- baphuthuma ngokuphuza utshwala noma ezinye izidakamizwa (ezifana ne-benzodiazepines, i-barbiturates, kanye nemithi yokulwa ne-antiepileptic)
- bathatha ezinye imithi equkethe i-bupropion (njenge-Wellbutrin no-Aplenzin)
- ungumsebenzisi ongapheli opioid
- ukhulelwe noma ukondla
- ziyalulaza kunoma yiziphi izithako ze-CONTRAVE
Akufanele futhi uthathe i-CONTRAVE ngesikhathi noma ezinsukwini ezingu-14 ngokuthatha i-monoamine oxidase inhibitors (MAOI).
Ososayensi abazi ukuthi ukuthatha i-CONTRAVE kuthinta kanjani impilo yakho yesikhathi eside yengqondo. Ngakho-ke uma usengozini yesifo senhliziyo, ungase ufune ukukhuluma nodokotela wakho mayelana nokulimala uma uthatha iphilisi yokudla. Umuthi wezidakamizwa uqhuba izifundo ukuze abone ukuthi iphilisi lokudla lihlangana kanjani nempilo yenhliziyo, kodwa imiphumela ayifanele kuze kube ngu-2021.
Okokugcina, abacwaningi abawazi nokuthi i-CONTRAVE ixhumana kanjani neminye imikhiqizo yokulahlekelwa kwesisindo njengemithi yokwelashwa, izidakamizwa ezingaphezu kwe-counter, kanye nezithako ze-herbal. Qiniseka ukuthi uvumele udokotela wakho wazi uma uthatha noma yimuphi omunye umuthi noma ukwelashwa okungagunyaziwe uma uxoxa ukuthi ngabe imithi ikufanele yini noma cha.
I-CONTRAVE Imiphumela Yokulahlekelwa Isisindo
Ngokwezifundo zemitholampilo, i-CONTRAVE ingasiza ekukhuthazeni ukulahleka kwesisindo, kodwa izinombolo azidli. Ekucwaningeni kweziguli ezingenaso isifo sikashukela, amaphesenti angu-42 weziguli alahlekelwe okungenani amaphesenti angu-5 wesisindo somzimba wabo ngemva konyaka. Lokhu kusho ukuthi abantu abaningi abathatha i-CONTRAVE abazange bahlangabezane nomgomo wamaphesenti angu-5.
Kwesinye isifundo, amaphesenti angu-57 weziguli ezithatha i-CONTRAVE elahlekelwe okungenani amaphesenti angu-5 wesisindo somzimba wabo. Kodwa amaphesenti angu-42 abahlanganyeli abathintekayo aphumile ohlelweni ngaphambi kokuba ucwaningo luqediwe. Iningi liye laphuma phakathi kwamasonto ambalwa okuqala.
Kulaba abagulayo abanesifo sikashukela, izinombolo zithobekile. Amaphesenti angamashumi amathathu nesithupha kweziguli alahlekelwe okungenani amaphesenti angu-5 wesisindo somzimba wabo ngemva konyaka. Kuzo zombili izifundo (iziguli ezinezifo ezingenaso nesifo sikashukela) iqembu elithatha indawo ye-placebo lalahlekelwa isisindo esincane kakhulu kuneziguli ezithatha i-CONTRAVE. Zonke iziguli kuzo zombili amaqembu zathola ukuguqulwa kwendlela yokuphila eyayiqukethe ukudla okuphansi kwekhalori nokuvivinya umzimba njalo.
Ngakho lokhu kusho ukuthini kuwe? Kubalulekile ukukhumbula ukuthi esifundweni ngasinye, iziguli ezithatha i-CONTRAVE nazo zenza izinguquko ohlelweni lwabo lokudla nokuzivocavoca. Ngakho-ke nakuba belahlekelwa isisindo ngephilisi yokudla (cishe amakhilogremu ayi-12 cishe ngonyaka) okunye kokulahlekelwa kwesisindo kwakungenxa yokushintsha kwendlela yokuphila (ukudla nokuzivocavoca) hhayi imithi.
Ngakho-ke, inani lesisindo olahlekelwayo lingase likwazi ukukwenza kahle ukuthi ugcine kanjani ukudla okunempilo, okulawulwa ngekhalori kanye nohlelo lokuzivocavoca.
IMIPHUMELA YEMIKHONO kanye nemiphumela emibi
Imiphumela emibi kakhulu ebikwa yiziguli ezithatha i-CONTRAVE zihlanganisa ukuhlukunyezwa, ukuqothulwa, ukukhanda ikhanda, ukuhlanza, ugozi, ukulala, ukulala, umlomo owomile kanye nokuhuda. Ekuvivinyweni komtholampilo, amaphesenti angu-24 abantu ayeke ukuthatha i-CONTRAVE ngenxa yemiphumela emibi. Amaphesenti angu-12 kuphela abantu abathatha i-placebo bayeke ukwelashwa.
Ngaphezu kwalokho, iphakheji liyadingeka ukuba ithwale isixwayiso sebhokisi elimnyama esitshela ukuthi abasebenzisi kufanele baqaphele ingozi eyengeziwe yokuzibulala kanye nokuziphatha kwabasakhulayo kanye nabantu abadala. Abantu abaye babhekana nokucindezeleka noma imania bangabona imibandela yabo babuya ngenkathi ku-CONTRAVE.
Njengoba lesi sidakamizwa sesivunyelwe yi-FDA, ochwepheshe bezokwelapha abaningana baye babonisa ukukhathazeka mayelana nokuthi kungenzeka yini ingozi ye-cardiovascular. Abanye baye bakhulume ukukhungatheka ngezikhangiso zethelevishini ezinciphisa izingozi nemiphumela emibi ye-CONTRAVE.
Ngenxa yalokho, ngo-2017, i-US Food Administration kanye neDrug Administration yanikeza isixwayiso kumenzi wezidakamizwa ethi indlela yokukhangiswa kwethelevishini yenziwe ngayo "inciphise ukuxhumana kolwazi olubalulekile lwengozi futhi ngaleyo ndlela ilahlekisa izingozi ezihlobene nokusetshenziswa koMphambano" inhlangano iyaqhubeka ithi "Isethulo kule vidiyo sinenkinga ngokukhethekile embonweni wezempilo yomphakathi inikeze izingozi ezinkulu futhi ezingase zisongela ukuphila ezihlobene nomuthi."
Uma uthola izikhangiso zenkampani ezikhangayo futhi uma ucabanga ukuthatha i-CONTRAVE, qiniseka ukuthi utshele umhlinzeki wakho wezempilo mayelana nayo yonke imithi oyithathayo njengoba kunezimo ezithile eziyingozi ezingase zenzeke uma imithi ethile ixhumana nayo. Uma usuqale ukuthatha iphilisi yokulahlekelwa isisindo, khuluma nodokotela wakho nganoma yiziphi izimpawu ezingavamile. Ngemuva kwamasonto angu-12 uma ungazange ulahlekelwe okungenani amaphesenti angu-5 wesisindo somzimba wakho, udokotela wakho cishe uzoyeka ukwelashwa kwakho nomuthi ngoba kungenzeka ukuthi le mithi izokusebenzela.
I-CONTRAVE Izindleko
Inombolo yePIRTRAVE yokudla amaphilisi ozithatha usuku ngalunye izonquma izindleko jikelele. Ngokusho kokuchaza ulwazi olunikezwe yinkampani, umthamo wakho uzohluka uma uqhubeka nokwelashwa.
Uma uqala ukuthatha i-CONTRAVE, ungathatha iphilisi elilodwa ngosuku. Njengoba uqhubeka nomuthi, umthamo uvame ukwanda. Ngeviki ezimbili, uthatha iphilisi elilodwa ekuseni kanti elinye ebusuku. Ngesonto lesithathu, uthatha amaphilisi amabili ekuseni kanye nobusuku. Ngemuva kwamasonto amane, umthamo ungakhuphuka ube ngamaphilisi amane ngosuku, kabili ekuseni kanye nobusuku.
Uzothola ukuthi izindleko ze-CONTRAVE zihluka kusuka kuma-dollar angu-99 ngenyanga ngaphezu kuka-$ 250 ngenyanga kuncike kumthamo, indawo, nokusakazwa komshuwalense. Umuthi wezidakamizwa unikeza uhlelo lwesiphakamiso sesaphulelo sesiguli esibhekene nomshuwalense ongafihli i-CONTRAVE noma ongenawo umshwalense. Ngekhadi lokulondoloza, ungahle ukhokhe imali engaphezu kwamaRandi angu-4 ngosuku ngosuku oluthile lwemithi.
Izwi elivela
Ukulahlekelwa isisindo kungaba inselele. Iphilisi lokudla lizwakala njengekhambi eliphelele. Kodwa ayikho imithi yokulahlekelwa isisindo esebenza kahle kuwo wonke umuntu. Khuluma nodokotela wakho mayelana nokudla kwakho nokuzivocavoca nomlando wakho wezokwelapha ukuthola ukuthi i-CONTRAVE ingase ikusebenzele. Uma unquma ukunikeza le mithi ukuzama, hlala uxhumane nethimba lakho lokunakekelwa kwezempilo uma ubona izimpawu ezingavamile noma izimpawu futhi ugcine ukuzibophezela kwakho okunamandla ekudleni okunomsoco nokuzivocavoca umzimba njalo ukuze uqiniseke ukuthi umzimba wakho uhlala uqinile futhi unempilo njengoba unciphisa phansi .
Imithombo:
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> Ukuphathwa Kwezokudla Nezidakamizwa zase-US. Izincwadi Zokuxwayisa NeSaziso Sokuhlukunyezwa Izincwadi Ezinkampanini Zezokwelapha. I-Orexigen Therapeutics, Inc. (Ukuphikisana) Incwadi Engenasihloko 5/18/2017