Ingabe kukhona ubufakazi obanele bokusekela ukusebenzisa le-supplement ukuze ulahlekelwe isisindo?
Isidakamizwa esingokwemvelo esinganciphisa ukufisa ukulamba, i-5-HTP (5-Hydroxytryptophan) yinzuzo ye-L-tryptophan, uhlobo lweprotheyini olutholakala ekudleni okuningana. Uma isetshenziswe njengesisindo sokulahlekelwa isisindo , i-5-HTP ivame ukuguqulwa emvelweni we- Griffonia simplicifolia plant.
I-5-HTP iyaziwa ukwandisa ukukhiqizwa kwe-serotonin ebuchosheni nasesimweni sezinzwa zomphakathi.
Uhlobo lwe-neurotransmitter (ikhemikhali elinomthwalo wokuthwala imiyalezo phakathi kwamangqamuzana omzimba), i-serotonin isiza ukulawula ukudla . Ngakho-ke, abanye abaxhasi bemithi ehlukile bathi ukusetshenziswa kwe-5-HTP kungasiza ekukhuthazeni ukulahlekelwa isisindo ngokugcina ukudla kwakho isheke bese kuthi kunciphisa ukudla kwakho.
Okushiwo yi-Research Mayelana Nezinzuzo Zama-5-Hydroxytryptophan
Ngokusho kweNational Institutes of Health (NIH), akusikho okwanele ubufakazi besayensi ukulinganisa ukusebenza kahle kokuthatha izithako ezingu-5-HTP zokulahlekelwa isisindo noma ukukhuluphala. Kodwa-ke, i-NIH iphawula ukuthi olunye ucwaningo lokuqala lubonisa ukuthi i-5-HTP ingasiza ekunqandeni ukudla, ukunciphisa ukudla kwe-caloric, nokunciphisa isisindo kubantu abakhulu kakhulu.
Ucwaningo olutholakalayo lubandakanya isifundo esidala kusukela ngo-1992 eshicilelwe eMelika Journal of Clinical Nutrition . Kulolu cwaningo, abangu-20 ababambe iqhaza abaye babelwa ngezikhathi ezithile ukuthola i-5-HTP noma i-placebo yezinkathi ezimbili zamasonto ayisithupha.
Nakuba kungekho ukudla okwakunqunywe esikhathini sokuqala sokutadisha, ukudla okuncishisiwe-ikhalori kunconywa okwesibili. Imiphumela yokufunda ibonise ukuthi amalungu eqembu le-5-HTP ahlangene nokulahlekelwa kwesisindo esikhulu phakathi kokubili izikhathi. Ngaphezu kwalokho, amalungu eqembu le-5-HTP ayenciphise ukudla kwe-carbohydrate kanye nokuthambekela kokuzwa ukuzwa (ukuzwa okuphelele) ekuqaleni kokudla.
Kwesinye isifundo (eshicilelwe kuyi- International Journal of Obesity and Related Metabolic Disorders ngo-1998), abacwaningi bathola ukuthi ama-5-HTP anciphisa kakhulu ukudla nsuku zonke kwama-calories nokuncipha kwesisindo somzimba kubantu abadala abakhuluphele ngokweqile nge-type 2 yesifo sikashukela. Ucwaningo lwabandakanya abantu abadala abangama-20 abanesifo sikashukela abanesifo sikashukela sohlobo lwesibili, abayisishiyagalolunye kubo banikezwa u-5-HTP no-11 banikwa i-placebo.
Kukhona ukungabi ncwaningo okwedlule mayelana nokusebenza kwe-5-HTP ekukhuthazeni ukulahlekelwa kwesisindo.
Imiphumela emibi kakhulu engabonakala ye-5-HTP
Ngokusho kwe-NIH, ukusetshenziswa kwe-5-HTP izithako kungaxhunyaniswa ne-eosinophilia-myalgia syndrome (EMS), isimo esibucayi esibangela ukuhlukumeza ngokweqile nangokwegazi okungavamile.
Ngo-1989 no-1990, kwakukhona isifo se-EMS phakathi kwabantu ababengenise i-L-tryptophan (i-pre-to-5-HTP). Lapho uphenyo, lesi sifo sasibuyele emthonjeni owodwa futhi sibhekiswe ekungcoleni okubangelwa ukuhlanzwa okungenele kanye nenqubo yokuvuthwa entsha. Nakuba ukuhweba kwe-5-HTP kungabasebenzisi izinqubo ezinjalo zokuvutshelwa, i-NIH icebisa ukugwema ukusetshenziswa kwe-5-HTP izithako kuze kuthiwa okwengeziwe ngokuphepha kwabo.
Kubalulekile ukukhumbula ukuthi ama-supplements awazange ahlolwe ukuphepha kanye nezondlo zokudla ngokuvamile azihambisani nomthetho.
Kwezinye izimo, umkhiqizo ungase ulethe ukulinganisa okungafani nesilinganiso esicacisiwe semifino ngayinye. Kwezinye izimo, umkhiqizo ungangcoliswa nezinye izinto ezifana nezensimbi. Futhi, ukuphepha kwezidakamizwa kwabesifazane abakhulelwe, omama abahlengikazi, izingane, nalabo abanezimo zezokwelapha noma abaphuza imishanguzo azange zisungulwe.
I-5-HTP yaziwa futhi ukuthi idale inani lemiphumela emibi, kufaka phakathi:
- Ukuguquka kwenhliziyo
- Ubuhlungu besisu
- I-nausea
- Ukuvota
- Uhudo
- Ukulala
- Izinkinga zobulili
- Izinkinga zemisipha
Ukwazi ukusebenzisana kwezidakamizwa ezingu-5-HTP
Ngaphezu kwalokho, ukuthatha ama-5-HTP kuhlanganiswe nemithi ethile kungenza imiphumela emibi.
Le mithi ihlanganisa izidakamizwa zokucindezeleka (njenge-Prozac® ne-Zoloft®), i-dextromethorphan (i-Robitussin DM®, nabanye), ne-meperidine (i-Demerol®). I-5-HTP ingabuye ihlanganyele nezinamba eziningi ze-herbal, okufaka phakathi i-St John's wort ne-S-adenosylmethionine.
Ungathola amathiphu engeziwe okusebenzisa izithako lapha.
Ukusebenzisa i-5-HTP ye-Weight Loss
Ngenxa yokukhathazeka kokuphepha, i-NIH iyala ngokumelene nokuthatha i-5-HTP kwifomu lokufakazela. Ngaphezu kwalokho, kukhona ubufakazi obuncane bokusekela isimangalo sokuthi ama-5-HTP angeziwe angakusiza ukulahlekelwa isisindo.
Uma ucabangela ukusebenzisa ama-5-HTP ama-supplement wokulahlekelwa isisindo (noma nganoma iyiphi enye injongo ehambisana nempilo), kubalulekile ukubonisana nomhlinzeki wakho wokunakekelwa ngaphambi kokuqala uhlelo lwakho lokwengeza. Ukuzitholela nokugwema noma ukubambezela ukunakekelwa okujwayelekile kungaba nemiphumela emibi.
Imithombo:
I-Bell SJ, i-Goodrick GK. "Umkhiqizo wokudla osebenzayo wokuphathwa kwesisindo." Crit Rev Rev Food Sci Nutr. 2002 Mar; 42 (2): 163-78.
Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Antonucci F, Rossi-Fanelli F. "Ukudla kokuziphatha nokunamathela emithethweni yokudliwa kwabantu abadala abaphathwa kabi nge-5-hydroxytryptophan." I-Am J Clin Nutr. 1992 Nov; 56 (5): 863-7.
Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. "Imiphumela ye-oral 5-hydroxy-tryptophan ekukhethweni kwamandla kagesi kanye nesimo se-macronutrient kwiziguli ezingezona isifo sikashukela ezingezona insulin." I-Int J Obes Relat Metab Disord. 1998 Jul; 22 (7): 648-54.
Hendricks EJ, Rothman RB, Greenway FL. "Ochwepheshe bokukhuluphala ngokweqile basebenzisa izidakamizwa ukuphatha ukukhuluphala ngokweqile." Ukukhuluphala (i-Silver Spring). 2009 Sep; 17 (9): 1730-5.
Izikhungo zezempilo zikazwelonke. "5-HTP: Izithako ze-MedlinePlus." Meyi 2011.
Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela olayisensi. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.