Izakhi zethu zofuzo, nezinye izici, sinquma ukuthi i-caffeine isithinta kanjani
Ukukhathazeka kwe-Caffeine kubhekisela ekuthini ukuthi kuthinta kanjani i-caffeine emzimbeni wethu. Abantu abanezinzwa ezingavamile ze-caffeine bangathola izimpawu eziphawulekayo - njengokukhathazeka, ukuthuthumela, ukukhanda ikhanda, ukushaya indlebe nokushona - emva kokudla ngisho nokudla okuncane okwenziwe nge-caffeine, Abantu abane-caffeine ukuzwela kufanele bazama ukugwema i-caffeine ngokuphelele.
Ukukhathazeka komuntu ukuthi i-caffeine inqunywa yizinto eziningana ezihlanganisa iminyaka nobulili, kodwa into enkulu kunazo zonke izakhi zofuzo. Kwabesifazane, ukuzwela kwe-caffeine kubuye kusetshenziswe kahle ngokusetshenziswa kwezizalo zokubeletha, nangokukhulelwa.
Indlela i-Caffeine isetshenzisiwe ngayo
I-caffeine isheshe isuke emathunjini ibe ngegazi, futhi iwela kalula ingozi yegazi-ebuchosheni. Futhi iwela ngokukhululekile i-placenta kwabesifazane abakhulelwe.
Esikhathini sobuchopho, i-caffeine ibophezela ku-adenosine receptors, ngaleyo ndlela ivimbela i-adenosine ukuba ingawahlanganisi. Ngoba i-adenosine ithumela ubuchopho umyalezo ukuthi sekuyisikhathi sokulala, ukuvimbela i-adenosine receptors inomthelela wokuvusa.
I-caffeine ixiliswa esibindi nge-enzyme ebizwa ngokuthi i-CYP1A2 i-theophylline, i-paraxanthine ne-theobromine, futhi isuswa ngamazinyo emcinini. Ukuphila kwengxenye ye-caffeine ngokuvamile kuvamile amahora angu-4 kuya kwangu-6, okuyinto ngokuvamile ukuthi i-caffeine isithinta kanjani isikhathi eside.
Yini Ethinta Ukuzwela Kwe-Caffeine?
Ukuzwela kwe-caffeine ngokuyinhloko kunqunywa umsebenzi we-CYP1A2 enzyme esibindi. Uma sisebenza ngokwengeziwe i-CYP1A2, sizwela kakhulu ukuthi siyi-caffeine. Izici eziningana zithinta umsebenzi we-CYP1A2:
- ubudala: Umsebenzi we-CYP1A2 uthambekela ekuncipheni ngeminyaka, ngakho-ke abantu asebekhulile bavame ukuzwela kakhulu i-caffeine
- ubulili: abesifazane bavame ukuba nomsebenzi ophansi we-CYP1A2 kunamadoda.
- Ukusetshenziswa komlomo ngokweqile nokukhulelwa: i-estrogens inqanda umsebenzi we-CYP1A2, futhi ukwanda kwe-caffeine
- Ukwenziwa kwe-Genetic: Kunezici eziningi ezihlukahlukene zezakhi zofuzo manje eziye zithinta umsebenzi we-CYP1A2.
I-Genesini yethu ne-Caffeine Sensitivity
Ukuvivinya umzimba kuveze imikhakha emithathu ejwayelekile ye-caffeine ukuzwela okuhlobene ne-genetic makeup yethu:
- I-Caffeine enamandla kakhulu: Laba bantu banomsebenzi ophansi kakhulu we-CYP1A2. Bayothola impendulo enamandla ngisho nakancane amakhemikhali e-caffeine, futhi ngokuvamile bayothola ama-jitters nokulala.
- Ukuzwela okujwayelekile ngokweCafeine : Lena iningi labantu ngabanye. Bangadla ku-400 mg we-caffeine ngosuku ngaphandle kwemiphumela emibi.
- Ukuzwela okuphansi kweCafeine : Laba bantu banomsebenzi omkhulu kakhulu we-CYP1A2, futhi ngokuvamile abazuzi nhlobo nhlobo kusukela ekudleni i-caffeine. Ababhemayo bavame ukwandisa umsebenzi we-CYP1A2.
Nakuba ukuhlolwa kofuzo kungahlukanisa izinga lakho lokuzwela kwe-caffeine, ukuhlolwa okusemthethweni ngokuvamile akudingekile ukuba wazi - okungenani ngokuvamile ukukhuluma - noma ngabe uzwela kakhulu nge-caffeine. Futhi uma kunjalo, kungenzeka ukuthi akekho umuntu okudingeka akutshele ukuthi unqande emuva.
Ukukhulelwa nokuzwela kweCafeine
Ukukhulelwa ngokwethembeka kukhulisa ukuzwela kwe-caffeine. Ukuphila kwengxenye ye-caffeine kwabesifazane abakhulelwe kuvame ukuphindwe izikhathi ezine kunabesifazane abangakhulelwe - ngokuvamile kuya kumahora angu-16. Ngaphezu kwalokho, i-caffeine ingena kalula egazini le-fetus - kanti ingane isuke ibe nomsebenzi omncane kakhulu we-CYP1A2. Ngenkathi imiphumela emibi kakhulu ebusweni obangelwa ukudla kwe-caffeine kamama ayizange ibhalwe phansi, le ndaba ayizange ifunde kabanzi. Ngokuvamile, abesifazane abakhulelwe kufanele bazame ukunciphisa noma ukugwema i-caffeine.
> Imithombo:
> Cornelis MC, Byrne EM, Esko T, et al. I-Coffee ne-Caffeine Genetics Consortium. Ukuhlaziywa kwe-meta-wide-generated-genome kubonisa izinombolo eziyisithupha ze-noci ezihlotshaniswa nokusetshenziswa kwekhofi evamile. I-Psychiatry ye-Molecular 20, 647-656 (Meyi 2015) | doi: 10.1038 / mp.2014.107
> Grant DM, Tang BK, Kalow W. Ukuhlukahluka kwe-caffeine metabolism. I-Clinical Pharmacology & Therapeutics, 33 (5), 591-602, 1983.
> Grosso LM, Bracken MB. I-caffeine metabolism, izakhi zofuzo, kanye nemiphumela yokuphazamiseka komzimba: ukubuyekezwa kokucubungula ukuhlolwa kokucwaninga ngesikhathi sokukhulelwa. Ann Epidemiol 2005; 15: 460.