Ukukhuluphala ngokweqile kuyaqhubeka kube isifo esiwumkhuhlane esithinta abadala nabantwana. Ngokusho kweNational Institutes of Health, kuye kwaba nokwanda okusheshayo kwabantu ababhekene nokukhuluphala ngokweqile noma okukhuluphele eminyakeni engu-20 edlule. I-metabolic syndrome nayo iyaba yilabo abakhuluphele kakhulu noma abakhuluphele kakhulu. I-syndrome ye-metabolic iqoqo lezinto eziyingozi ezikhulisa amathuba omuntu wesifo senhliziyo nokugula.
Usizo lokukhuluphala
Ukukhuluphala ngokweqile kuyinkinga yempilo yomhlaba wonke eyenza ucwaningo olungapheli ukuthola izindlela zokunciphisa amafutha omzimba nezifo ezihlobene. Ukukhuluphala nokuqhathaniswa ngokweqile kuboniswa ukuthi yizona zizathu eziyinhloko zesifo se-metabolic syndrome. Ucwaningo olunyatheliswa eNational Institutes of Health lubonise ukukhishwa kwe-hop okufakiwe (IHE), isithako esibabayo ebhiya ukuvimbela ukukhuluphala okubangelwa ukudla. Izifundo ze-hop acids eziqhubekayo zenzelwe ngamagundane nabantu ukuze ziqinisekise lezi zithole.
AmaHops nokulahlekelwa kwe-Fat
AmaHops yiyona isithako esiyinhloko ebhiya kanye nesinye isikhathi sesitshalo samantombazane (humulus lupulus L.) . I-acids e-hops inikeza ubhiya iphunga elibabayo. Inqubo yokuphuza nokugcina idala isakhi esincane esibabayo esibizwa ngokuthi i-matured hop acry acids (MHBA). I-MHBA iboniswe ukusiza ukunciphisa amafutha omzimba kokubili abantu namagundane.
Kuthiwa i-Acured hop acid acry (MHBA) yokwandisa i-thermogenesis (ukukhiqizwa kokushisa) emzimbeni. Ukushisa okuvela ku-thermogenesis kuboniswa ukuthuthukisa ukushisa kwamafutha nokulahlekelwa isisindo. I-MHBA iphinde iphakanyiswe ukwandisa uketshezi lwe-lipid (fat) esibindi futhi igweme ukuxhuma kwamafutha emathunjini. Ngamanye amazwi, izinhlanzi zibonakala zishisa amanye amafutha aqoqwe ngenye isibindi futhi azivimbela ukungena emithanjeni yethu yegazi.
AmaHops kanye namafutha omncuba
Ucwaningo olunyatheliswa eNational Institutes of Health luvivinye ama-acids e-matured hop acwebe (MHBA) ngamagundane. Inhloso yalolu cwaningo kwakuwukubonisa i-MHBA ukunciphisa izitolo zomzimba zomzimba ezidliwayo kulezi ziphuphu kanye namagundane. Abacwaningi bagxile kumafutha athile okuthiwa ama-adipose tissue brown (BAT) ngesikhathi sokuhlolwa.
Izicubu ezincane ze-adipose (BAT) eyinhloko ukukhiqiza ukushisa komzimba. I-BAT inama-capillari amaningi nama-lipids uma kuqhathaniswa nama-fat fat cells. Ngenxa yokuthi i-BAT iyisisulu esiningi idinga oksijini ngaphezulu. Amafutha omnyovu nawo anezinzwa ezingenayo i-stimulating cell cells. Enye yemisebenzi ye-BAT isenza sithuthukise ukwandisa izinga lokushisa lomzimba lapho sibanda. Amafutha aluhlaza nawo kuthiwa iyisitho esisebenzayo esinamandla okunciphisa amandla omzimba.
Ucwaningo kanye nezidakamizwa
Ama-acids amathanga wokubamba ama-hop (i-MHBA) ahlolwe ngamagundane anikezwe ukudla okunamafutha aphezulu ukuze enze ukukhuluphala. I-MBHA ibonise ukuthi isithako esihle ebhiya ukusiza ukunciphisa amafutha omzimba anqwabelene nemikhuba emibi yokudla.
Zombili amagundane namagundane bafundiswa ngaphansi kwezivumelwano ezivivinya ukuhlolwa kwemitholampilo. Amagundane ayehlukaniswe ngamaqembu amabili kokubili kokuthola ukudla okunamafutha aphezulu (HFD). Iqembu elilodwa lathola ukulawulwa kwe-hop ukubhuka ama-acids (MHBA noma i-MHB) ngaphezu kwe-HFD yabo. I-MHB yanda kancane kancane eqenjini lokulawula ngaphezu kwesonto lesishiyagalolunye. Isisindo somzimba sasilinganiswa izikhathi ezimbili ngesonto ngesikhathi kuhlolwa. Amasampula wegazi namathambo athathwe ekupheleni kwesilingo.
Imiphumela yocwaningo yamagundane aphethwe ama-acids actering bittering acids (MHBA noma i-MHB) kanye nokudla okunamafutha aphezulu (HFD) abonisa ukuzuza kwesisindo kakhulu. Futhi kuboniswe ukuthi kuncipha emathisini amhlophe adipose (amafutha) futhi kugodliwe amafutha e-acids mahhala egazini legazi. Okunye okutholakele kwakuhlanganisa amazinga akhulisiwe we-messenger ribonucleic acid (i-mRNA) eyisifanekiso seprotheyini synthesis (ukukhula) . Le miphumela ibonisa ukuthi i-MHB igqugquzela ukwanda kwe-mRNA ethize ku-thermogenesis (evuthayo) yamafutha asundu.
Ukutholakala kwamagundane okudla ama-acid actering bittering acids (i-MHBA noma i-MHB) ngokudla okunamafutha aphezulu kubonisa ukuphakama okukhulu kwezicubu ezi-brown adipose (BAT) kanye nomsebenzi we-neural ozwelayo (SNA). Kuboniswa ukuthi i-MHB igqugquzela ukuphela kwezinzwa ezikhuthaza ukushisa kwe-thermogenesis (ukushisa) kwamafutha asundu.
Imiphumela ephelele yabonisa ukuthi ama-acids akhazimulayo ama-acids (MHBA noma i-MHB) njengesizo esiwusizo sokushisa ama-brown emagundeni. I-MHB nayo yaboniswa ukusiza ukuqoqwa kwamafutha omzimba okudliwayo. Nakuba kudingeke ucwaningo olwengeziwe, kubonakala sengathi i-MHB ingaba isithako esiwusizo ekudleni naseziphuzweni ukuze "unciphise ukuqoqwa kwamafutha omzimba okudliwayo kanye nokuphazamiseka okuhambisana nomzimba ."
I-Human Studies
Ucwaningo lwanyatheliswa eNcwadini Yomsoco ehlola ukuthi amathrekhi akhuphuka kanjani ehliswayo anciphisa amafutha omzimba kubantu abanempilo enamandla kakhulu. Ucwaningo lubandakanya abantu abangamakhulu amabili abahlanganyeli besilisa nabesifazane. Laba bantu babephakathi kweminyaka engu-20 no-64 ubudala benombhalo womzimba womzimba (BMI) wama-25 kuya kwangu-30 kg / m² futhi ngezikhathi ezithile babekwa ngamaqembu amabili. Umuntu ngamunye waba nesifo socansi lwe-CT esiswini ukuze ahlole ama-abdominal, ukuhlolwa kwegazi kanye nomchamo njengengxenye yenqubo yokutadisha.
Ngesikhathi sokuhlolwa kwamasonto ayishumi nambili, izihloko ziphuza isiphuzo se-350ml esinezikhumba ezivuthiwe ezikhishwe (MHE) zihlanganiswe nama-acids ekhulile e-hop (MHBA) noma i-placebo. Iziphuzo ezisebenzayo nezingezona ezisebenzayo zibuke futhi zinambitha okufanayo. Amarekhodi anembile wokudla, ukuvivinya umzimba nokugcoba kwe-MHE agcinwe kulo lonke ucwaningo. Noma yimiphi imiphumela emibi yempilo nayo yaphawulwa.
Ukuthola okuyinhloko eqenjini ukuphuza iziphuzo ezivuthiwe ze-hops (MHE) isiphuzo esibonisa ukwehla okuphawulekayo kumafutha esiswini emasontweni ayisishiyagalombili neshumi nambili kuqhathaniswa nabahlanganyeli be-placebo. Imiphumela yesibili yeqembu elidlayo i-MHE lalikhulu kakhulu ukulahlekelwa isisindo futhi ngcono umzimba body index (BMI). Ukuncipha kwama-fat percentage ratio kwaba ngcono nakakhulu kulabo abaphuza i-MHE. Ngemuva kwamasonto amane, iqembu elixhasayo ne-MHE laqaphela isisindo esincane nesisindo se-hip uma kuqhathaniswa nabahlanganyeli be-placebo. Abantu abazange babe nemiphumela emibi ehlobene nesiphuzo sokuhlolwa ngesikhathi sokucwaninga.
Izitshalo ezikhulayo ezikhulile (MHE) ngokusekelwe kokuthola, aziqukethe i-isoacids eyanele ukuba nomthelela ekukhulupheni. Abacwaningi baphetha ama-acids okuvuthiwe ama-acids acacile (MHBA) esiphuzweni sokuhlolwa njengoba i-compound ikhuthaza ukulahlekelwa kwamafutha . Ucwaningo lubonise ukuthi i-MHE ihlanganiswe ne-35mg MHBA yayiphumelele ekunciphiseni amafutha omzimba. Izifundo eziqhubekayo ziyadingeka kodwa kubonakala sengathi i-MHE ingaba "ithuluzi eliwusizo futhi eliphephile ukuvimbela ukukhuluphala nokukhathazeka okuhlobene nokuqubuzana komzimba."
Ingabe Ukuphuza Ubhiya Ukunikeza Inzuzo Efanayo?
Nakuba ubhiya buqukethe ama-hops avuthiwe nama-iso-acid, akuqukethe ukugxila okuphumelelayo ukunciphisa amafutha esiswini . Ngakho-ke, impendulo yalo mbuzo ingukuthi, cha. Ukwedlula ukwedlula kwalesi siphuzo esidala sekhalori esiphezulu kuhlanganiswe nokuzuza kwesisindo kanye nezinye izinkinga zempilo. Futhi, izifundo ezibuyekezwe kulesi sihloko zihlolisisa i-hops ehlanganisiwe ehlanganiswe nobhiya.
Ingabe Itholakala Kwifomu Yokungezelela?
Ama-hops acids acids (MHA) asetshenziswe imithi iminyaka. Ukucwaninga kubonisa ukuthi i-MHA iyasiza njengendlela yokudambisa futhi isetshenziswe njengengculaza. Ngokwesifundo eshicilelwe ku- Molecular Nutrition and Research Research, i- hop acid evuthiwe ivinjisa ngokuphumelelayo ukuvuvukala kwendawo. I-MHA ingathengwa njengesengezo esingalawulwayo ngenhloso yokwelapha. Ucwaningo lwezokwelapha luyaqhubeka olwenziwe ngama-hops avuthiwe acids elisetshenziselwa ukushisa amafutha noma ukucindezela. Ukuthola okucwaningweni kulungile futhi kubonakala sengathi izinhlanganisela ezisebenzayo ezikhaleni maduzane zizobhekwa ngokuthi "ukwelashwa kokudla okunomsoco" okusiza izifo ezingapheli ezihlobene nesifo se-metabolic syndrome.
Imithombo:
I-Biomed Central, I-Nutrition Journal, i-Matured hop extract iyanciphisa amafutha omzimba kubantu abanempilo enempilo kakhulu: isifundo seqembu elifanayo elihleliwe, elingenakubili, eliyimpumputhe, elibhekene ne-placebo, u-Yulie Morimoto-Kobayashi et al., 2016
Ama-Institutes of Health, Abstract, Matured Hop Components Induce I-Thermogenesis ku-Brown Adipose Tissue nge-Sympathetic Nerve Activity, i-Morimoto-Kobayashi Y et al., 2015
I-International Journal of Obesity, Ukuvimbela ukukhuluphala okubangelwa ukudla ngokweqile yi-extract isomerized hop extract equkethe ama-isohumuloni, ngamagundane, i-Yajima H et al., 2005
Izikhungo Zempilo Zomphakathi, uMnyango WezeMpilo Nezinsizakalo Zabantu, Izihloko Zezempilo, Kuyini Ukuxilongwa Kwama-Metabolic Syndrome? 6/16
Ukudla Kwamakhemikhali Nokucwaninga Kwokudla, ama-ac acid ababayo avimba kahle ukuvuvukala okuzimele ku-GRALpha, PPARalpha, noma i-PPARmma, u-Van Cleemput M et al., 9/09